Steve MacDonald-Brown MRSC, PGCert — 30+ years delivering practical, GMP-aligned solutions from mmol to multi-litre, across pharma, fine chemicals, and R&D.
From bench to pilot: robust routes, reproducible yields, and practical hazard mitigation. Experience in fractional/vacuum distillation and high-pressure hydrogenations.
NMR, DSC, HPLC, KF, LC-MS. Root-cause analysis, data integrity, and getting stubborn chemistry to behave.
Risk identification, SOP development/refinement, and building a proactive lab safety culture aligned to GMP expectations.
Member, Royal Society of Chemistry.
Postgraduate Certificate – ongoing professional development.
Solid forms of a plasma kallikrein inhibitor and salts thereof
WO2019106377A1 · Named inventor · Published 6 June 2019.
Accessing New Phenanthroline–Oxazine Scaffolds as Copper-Dependent DNA Damaging Probes
ChemBioChem, 2026, 27(8), e202500874.
Co-author · Cover Feature.
Development of new amino-acid-derived phenanthroline–oxazine ligands and investigation of their copper-dependent DNA-binding and damaging properties.
I’m currently developing NMR Analyst, a desktop application for viewing, organising and interpreting NMR data, designed from a practising chemist’s perspective.
Cornwall-based. Remote UK/EU or onsite by arrangement. Flexible for consultancy, contract, or interim assignments.
Semper Quaerimus Inusitatum — “we always seek the unusual.”
Banner image captured by Steve (Henize 70, supernova remnant).